What causes elevated levels of serum creatine kinase isoenzymes?

Under normal circumstances, elevated serum creatine kinase (CK) isoenzyme levels may be caused by intense physical exercise, medication effects, polymyositis, myocarditis, or myocardial infarction. If you experience any discomfort, it is recommended to seek medical attention promptly. Detailed analysis is as follows:

1. Intense Physical Exercise

During intense physical activity, muscle tissues may become damaged due to increased metabolism, leading to the release of creatine kinase isoenzymes from muscle cells into the bloodstream, thereby increasing their levels. This condition typically does not present with specific accompanying symptoms and usually requires no special treatment.

2. Medication Effects

Long-term use of lipid-lowering drugs such as statins or antipsychotic medications may cause muscle damage, resulting in elevated serum creatine kinase isoenzyme levels. It is recommended to discontinue or adjust these medications under a doctor's supervision.

3. Polymyositis

Damage to muscle tissue may trigger polymyositis, causing creatine kinase isoenzymes to be released from muscle cells into the blood, thus increasing serum CK isoenzyme levels. Symptoms may include joint pain and rashes. It is recommended to follow a doctor’s advice and use medications such as prednisolone acetate tablets, dexamethasone tablets, or cyclosporine soft capsules for treatment.

4. Myocarditis

Bacterial infections may lead to myocarditis, and the inflammatory response can cause damage to myocardial cells and the release of creatine kinase isoenzymes into the bloodstream, resulting in elevated serum CK isoenzyme levels. Common symptoms include palpitations and arrhythmias. It is recommended to follow medical advice and use medications such as Guanxin Danshen dripping pills, Wenxin granules, or Ribavirin granules for treatment.

5. Myocardial Infarction

Myocardial infarction may occur due to ischemia, hypoxia, and necrosis of myocardial cells, leading to a large amount of creatine kinase isoenzyme being released into the bloodstream, significantly increasing serum CK isoenzyme levels. Symptoms often include chest tightness and arrhythmias. It is recommended to use medications such as nitroglycerin tablets, metoprolol tartrate tablets, or clopidogrel hydrogen sulfate tablets under a doctor’s guidance.

In daily life, appropriate physical exercise can be increased to enhance physical strength and boost immune function.