Does the cholera vaccine have to be administered three times consecutively?

Generally, the cholera vaccine requires three consecutive doses. The detailed explanation is as follows:

Cholera is an acute intestinal infectious disease caused by Vibrio cholerae, primarily transmitted through contaminated water or food. Symptoms include severe diarrhea, vomiting, and dehydration. Vaccination against cholera is one of the effective methods to prevent this disease. The strategy of administering multiple doses is mainly intended to enhance immune response, ensuring the body produces sufficient antibodies to protect against V. cholerae infection. After the first dose, the body begins to generate an immune response; however, this initial response may be relatively weak and insufficient for long-term protection. Repeated vaccinations progressively stimulate the immune system, allowing antibody levels to rise gradually and reach a stable state, thereby providing durable and effective immunity. Additionally, multiple doses help improve the vaccine's safety and tolerability, reducing the likelihood of adverse reactions.

While receiving the vaccine, individuals should also maintain good personal hygiene practices, avoid consuming raw or undercooked food, and refrain from drinking untreated or unsterilized water to further reduce the risk of contracting cholera.