Why is the quadrivalent vaccine not recommended?

Nov 12, 2024 Source: Cainiu Health

Dr. Yang Ziqi

Introduction

In general, quadrivalent vaccination may not be recommended due to reasons such as immune system disorders, history of allergies, inappropriate age, special periods in women (e.g., pregnancy or menstruation), or fever. It is important to ensure adequate rest, avoid strenuous exercise, maintain a light diet, and closely monitor bodily reactions to optimize vaccine effectiveness. If any adverse effects occur, prompt medical attention is advised.

Generally, the quadrivalent vaccine refers to the quadrivalent HPV vaccine, which is a type of human papillomavirus vaccine. There are several reasons why receiving the quadrivalent HPV vaccine may not be recommended, including immune system disorders, history of allergies, inappropriate age, special periods in women (such as menstruation, pregnancy, or breastfeeding), and fever. If any discomfort occurs, it is advisable to seek medical attention promptly. The specific analysis is as follows:

1. Immune system disorders

The quadrivalent HPV vaccine contains weakened or attenuated viruses. Patients with immune system disorders may have abnormal immune responses, and vaccination could potentially worsen their condition or trigger adverse reactions.

2. Allergy history

Individuals with a history of allergic reactions to vaccine components—especially those who have had severe allergic reactions to any ingredient in the vaccine, such as yeast or antibiotics—should avoid receiving the vaccine.

3. Inappropriate age

The recommended age range for receiving the quadrivalent HPV vaccine is 20 to 45 years. Vaccination is generally not advised for individuals younger than 20 or older than 45.

4. Special periods in women

Vaccination is not recommended during menstruation, pregnancy, or breastfeeding, as these physiological states may affect the safety and effectiveness of the vaccine.

5. Fever

When a woman has a fever, her immune system is typically weakened. Receiving the quadrivalent HPV vaccine under such conditions may increase the risk of adverse reactions and could impair the body's ability to produce protective antibodies.

In daily life, it is important to ensure adequate rest, avoid strenuous exercise, maintain a light diet, and closely monitor bodily responses to help ensure optimal vaccine efficacy.

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Can I still receive the 9-valent vaccine after having received the 4-valent vaccine?

"Quadrivalent" refers to the quadrivalent HPV vaccine, and "nonavalent" refers to the nonavalent HPV vaccine. It is possible to receive the nonavalent HPV vaccine after having received the quadrivalent HPV vaccine, but certain conditions must be met, and it is not mandatory. Neither the quadrivalent nor the nonavalent HPV vaccine can guarantee 100% protection against HPV. Even after receiving the HPV vaccine, regular cervical cancer screening should still be performed.

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Is it possible to receive the third dose of the cervical cancer vaccine after the age of 45?

If the recipient was under the recommended upper age limit when receiving the first two doses of the cervical cancer vaccine—45 years for the bivalent vaccine, 45 years for the quadrivalent vaccine, and 26 years for the nonavalent vaccine—and has completed the first two doses according to the prescribed vaccination schedule, then even if the recipient's age exceeds 45 years when receiving the third dose, vaccination can still proceed.