What are the three first-choice drugs for antiarrhythmic treatment?

There is generally no such thing as "three first-choice drugs for antiarrhythmia." Antiarrhythmia is commonly treated with medications such as Quinidine Sulfate Tablets, Lidocaine Hydrochloride Injection, Propafenone, Amiodarone Hydrochloride Tablets, and Verapamil Hydrochloride Tablets.

1. Quinidine Sulfate Tablets: Moderately block sodium channels in myocardial cell membranes, reduce the rising rate of phase 0 in action potentials, prolong the duration of action potentials and effective refractory period, suppress the automaticity of ectopic pacemakers, and slow conduction, used for various types of arrhythmia.

2. Lidocaine Hydrochloride Injection: Mildly block sodium channels, primarily acting on the His-Purkinje system, shortening the duration of action potentials, relatively prolonging the effective refractory period, reducing myocardial automaticity, with stronger effects on ischemic myocardium. It is a commonly used drug for treating ventricular arrhythmias.

3. Propafenone Hydrochloride Tablets: Block sodium channels, reducing the rising rate and amplitude of phase 0 in action potentials, slowing conduction, suppressing the automaticity of ectopic pacemakers, used for both supraventricular and ventricular arrhythmias.

4. Amiodarone Hydrochloride Tablets: Block potassium channels and also have blocking effects on sodium and calcium channels. It prolongs the action potential duration and effective refractory period of myocardial cells and is a broad-spectrum antiarrhythmic drug used for various supraventricular and ventricular arrhythmias.

5. Verapamil Hydrochloride Tablets: Inhibit calcium channels in myocardial cell membranes, reducing calcium ion influx, lowering the automaticity of sinoatrial and atrioventricular nodes, slowing atrioventricular nodal conduction velocity, and prolonging the effective refractory period. It is mainly used for supraventricular arrhythmias.

When selecting antiarrhythmic drugs, a comprehensive evaluation of the patient's underlying disease, type of arrhythmia, and cardiac function is necessary. Patients must strictly follow medical advice when taking medications, closely monitor bodily responses during treatment, and discontinue use immediately if adverse reactions occur.