It is essential to hold the suppository for several minutes.

There are two formulations of Glycerin Enema: one contains glycerin and the other contains mannitol and magnesium sulfate. Generally speaking, there is no standard recommendation that one "must hold for several minutes" after using a glycerin enema. If the constipation is mild, it is suggested to retain the enema for 5–10 minutes. For more severe constipation, retaining it for 15–30 minutes may be appropriate. The exact duration varies individually, and consultation with a healthcare professional is advised before use. Detailed explanation is as follows:

Glycerin Enema is a mild laxative used to relieve constipation. It works by using the high concentration (i.e., hyperosmotic effect) of glycerin or sorbitol to soften the stool and stimulate the intestinal wall, thereby reflexively inducing a bowel movement. If the constipation is mild, retaining the enema for 5–10 minutes allows the solution to mix thoroughly with the stool, effectively softening it and stimulating peristalsis, thus facilitating smoother defecation.

If the constipation is more severe and the stool is particularly dry and difficult to expel, a longer duration may be needed for the medication to take effect. Retaining the enema for 15–30 minutes may increase the likelihood of successful defecation. Some patients may feel a strong urge to defecate shortly after administration; in such cases, individuals may decide whether to proceed with defecation based on their own sensation.

Prior to using a glycerin enema, appropriate cleansing and disinfection should be performed to avoid infection or other adverse reactions. The procedure should be performed gently to prevent injury to the anus.