Can small three positives be cured?

Nov 23, 2024 Source: Cainiu Health

Dr. Gao Jun

Introduction

"Xiao San Yang" is a chronic hepatitis B virus infection status, where the hepatitis B virus persists in the patient's body and causes varying degrees of damage to the liver. If the patient has a low viral load and normal or mildly abnormal liver function, this condition is referred to as chronic hepatitis B. For such patients, timely standardized antiviral treatment, along with consistently stable liver function and effectively controlled viral load, is essential.

Generally, "small three positives" refers to a condition where the hepatitis B surface antigen, hepatitis B e antibody, and hepatitis B core antibody are all simultaneously positive. If a patient has a chronic hepatitis B viral infection, it may be difficult to achieve a cure; however, if the viral load in the patient's body is low, a cure may be possible. The analysis is as follows:

"Small three positives" is a state of chronic hepatitis B viral infection, in which the hepatitis B virus persists in the patient's body and causes varying degrees of damage to the liver. Because covalently closed circular DNA (cccDNA) exists in the nuclei of liver cells in patients with "small three positives," and there are currently no clinically available specific targeted therapies directed against cccDNA, it is impossible to completely eliminate the hepatitis B virus from these patients.

If a patient has a low viral load and normal or mildly abnormal liver function in the context of chronic hepatitis B, then with timely, standardized antiviral treatment and sustained stable liver function during treatment, the viral load can be effectively controlled and even become undetectable. The criteria for cure typically include the loss of hepatitis B surface antigen (HBsAg), or its long-term maintenance at a low level, along with normalization of liver function.

In daily life, patients should avoid unhealthy habits such as alcohol consumption and excessive fatigue to protect liver health.

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