What are the side effects and risks of Novartis?

During use, there may be some side effects and adverse effects, including hypotension, hyperkalemia, renal impairment, angioedema, abnormal liver function, and others. The drug name for Novartis's medication is sacubitril/valsartan sodium tablets, which is used for treating adult patients with chronic heart failure and reduced ejection fraction. If any abnormalities occur, timely medical attention is recommended. Detailed analysis is as follows:

1. Hypotension: Sacubitril/valsartan sodium tablets have the effect of dilating blood vessels and lowering blood pressure; therefore, long-term use may lead to hypotension. Patients with insufficient blood volume or electrolyte deficiency are at higher risk. Hypotension may cause symptoms such as dizziness and fatigue, and severe cases may result in syncope or shock.

2. Hyperkalemia: Sacubitril/valsartan sodium tablets act on the renin-angiotensin system and may cause elevated blood potassium levels, leading to hyperkalemia. Hyperkalemia may cause arrhythmia, nausea, vomiting, abdominal pain, and other symptoms.

3. Renal Impairment: Since sacubitril/valsartan sodium tablets are metabolized through the kidneys, long-term use may impair kidney function. Renal impairment may manifest as oliguria, progressive nitrogen retention, and even acute renal failure and death.

4. Angioedema: Sacubitril/valsartan sodium tablets may cause angioedema, which is a localized swelling occurring in loosely packed subcutaneous tissues or mucous membranes. Patients may experience symptoms such as skin swelling, redness, pain, and burning sensation. If the swelling occurs in the mucous membranes of the throat, it may lead to serious conditions such as difficulty breathing and swallowing.

5. Abnormal Liver Function: Although sacubitril/valsartan sodium tablets have minimal direct impact on liver function, long-term use may still cause some liver damage. Liver dysfunction may manifest as elevated transaminase levels, jaundice, and other symptoms.

Therefore, patients should regularly monitor indicators such as blood pressure, serum potassium, and kidney function during treatment to ensure safe medication use.