Will there be any consequences of taking ibuprofen when having a fever of 37.5℃?

Generally, common dosage forms of ibuprofen include tablets, capsules, and granules. Taking ibuprofen at a fever of 37.5°C may lead to consequences such as gastrointestinal discomfort, excessive sweating and dehydration, increased liver metabolic burden, allergic reactions, and masking of the true medical condition. A detailed analysis is as follows:

1. Gastrointestinal discomfort: As a nonsteroidal anti-inflammatory drug (NSAID), ibuprofen may irritate the gastrointestinal mucosa, causing symptoms such as nausea, vomiting, abdominal pain, and diarrhea. When taken at a low-grade fever, since the body is already in a state of stress, gastrointestinal function may be relatively weakened, making gastrointestinal discomfort more likely to occur.

2. Excessive sweating and dehydration: Ibuprofen has antipyretic and analgesic effects. After administration, it may cause profuse sweating to dissipate heat and lower body temperature. If fluids are not replenished promptly, dehydration symptoms such as thirst, fatigue, and dry skin may occur.

3. Increased liver metabolic burden: Ibuprofen needs to be metabolized and excreted through the liver. Administration at a low-grade fever may increase the liver's metabolic burden, leading to elevated transaminase levels or symptoms such as fatigue, fever, and abdominal distension. For patients with impaired liver or kidney function, this burden may be even more severe.

4. Allergic reactions: Some patients may develop allergic reactions to ibuprofen or its components, such as rashes and itching. In severe cases, life-threatening allergic reactions such as laryngeal edema and bronchospasm may occur. Although the probability of allergic reactions is low, attention should still be paid.

5. Masking of the true medical condition: Taking ibuprofen at a low-grade fever may mask the true underlying condition, making it difficult for physicians to accurately assess the cause and severity of the illness. This could lead to inappropriate treatment or delay in timely treatment, especially in the diagnosis and management of infections and inflammation.

When body temperature reaches 37.5°C, it is recommended to use physical cooling methods, such as drinking more water and warm water sponge baths, to help reduce body temperature. If physical cooling is ineffective or if the temperature continues to rise above 38.5°C, ibuprofen can be used for antipyretic and analgesic treatment under a doctor's guidance. During medication, close attention should be paid to the body's response, and medical attention should be sought promptly if any discomfort occurs.