What to do if urine β2-microglobulin is elevated

Normally, the causes of elevated urine β2-microglobulin levels may include strenuous exercise, excessive fatigue, diabetes, glomerulonephritis, and systemic lupus erythematosus. These conditions can be managed through appropriate scheduling of exercise duration and intensity, maintaining a positive mindset and emotional well-being, and medication therapy. Specific details are as follows:

1. Strenuous Exercise

During intense physical activity, the body's metabolism accelerates, placing increased strain on the kidneys and increasing the permeability of renal tubules. This may lead to increased excretion of β2-microglobulin into the urine, which should normally be reabsorbed, thereby potentially causing elevated levels of β2-microglobulin in the urine. Avoid prolonged strenuous exercise, schedule appropriate exercise duration and intensity, and allow for adequate rest and hydration after physical activity.

2. Excessive Fatigue

Long-term overexertion or excessive mental stress may lead to temporary kidney dysfunction, which could result in elevated urine β2-microglobulin levels. It is important to manage work and rest schedules appropriately, avoid excessive fatigue, and maintain a positive mental state and emotional stability.

3. Diabetes

Diabetes is primarily caused by genetic factors, obesity, environmental factors, and autoimmune conditions. Prolonged diabetes may lead to kidney damage, resulting in diabetic nephropathy, which alters the glomerular filtration rate and increases the permeability of the kidney's filtration membrane, potentially leading to elevated urine β2-microglobulin levels. This may be accompanied by symptoms such as increased thirst, frequent urination, increased appetite, and weight loss. Under the guidance of a qualified physician, medications such as orlistat capsules, acarbose capsules, and glimepiride tablets may be used for treatment.

4. Glomerulonephritis

Glomerulonephritis is typically caused by infections, autoimmune diseases, medications, or other factors. Glomerulonephritis impairs the filtration function of the glomeruli, preventing β2-microglobulin from being properly filtered and excreted in the urine, thereby increasing its concentration in the urine. Symptoms may include hematuria, proteinuria, edema, and hypertension. As directed by a physician, treatment may involve medications such as furosemide injection, captopril tablets, and cyclosporine soft capsules to alleviate symptoms.

5. Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease whose onset is associated with multiple factors including genetic predisposition, environmental influences, and immune dysfunction. SLE may affect the kidneys, leading to lupus nephritis, which impairs glomerular filtration function and increases the excretion of β2-microglobulin. Symptoms may include fever, joint pain, rash, and oral ulcers. Under the guidance of a qualified physician, treatment may involve medications such as clobetasol propionate cream, danazol capsules, and methylprednisolone tablets.

In daily life, it is important to get adequate rest and avoid excessive fatigue. Maintain a diet low in salt and fat, and consume high-quality, low-protein foods.