Is it necessary to fast before a liver function test?

Dec 30, 2024 Source: Cainiu Health
Dr. Gao Jun
Introduction
When undergoing liver function tests, it is generally necessary to remain fasting to ensure the accuracy of the test results. After eating, food is metabolized by the liver, which may cause changes in the concentration of certain components in the blood. Particularly after consuming high-protein or high-fat meals, liver enzymes such as transaminases and serum proteins may increase, potentially leading to inaccurate test results.

Generally, a liver function test requires fasting. The detailed explanation is as follows:

After eating, food is metabolized by the liver, and some nutrients may enter the bloodstream, potentially altering blood concentration and even affecting blood quality. Moreover, consuming high-protein or high-fat foods might cause elevated levels of alkaline phosphatase, gamma-glutamyl transferase (GGT), other transaminases, and serum proteins in the liver, which could interfere with the accuracy of the test results. Therefore, it is usually recommended to fast for 8–12 hours before the test to ensure accurate results.

In addition to fasting, patients should also control their physical activity before undergoing a liver function test and avoid strenuous exercise such as running or jumping rope. Furthermore, regular monitoring is necessary after the test, and any discomfort should be promptly reported to a physician.

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