Can watermelon really neutralize the effects of medicine?
Generally speaking, watermelon does not possess properties that counteract medications. Detailed analysis is as follows:

Watermelon contains large amounts of water, fructose, vitamins, and dietary fiber. It has diuretic, thirst-quenching, and heat-clearing effects. Moderate consumption can aid digestion and relieve heat discomfort. These components and benefits make watermelon an ideal summer refreshment, but they do not imply that watermelon has the ability to neutralize medications.
Watermelon itself does not have the function of counteracting the effects of medications. During medication treatment, moderate consumption of watermelon generally will not interfere with drug efficacy. However, to avoid potential drug interactions or influence on drug absorption, it is recommended to avoid consuming excessive amounts of watermelon, especially chilled watermelon, for a period of time before and after taking medication. The water content in watermelon may dilute gastric juice, thus affecting the absorption of certain medications that require an acidic environment. Additionally, some components in watermelon might interact with diuretics, enhancing their diuretic effects.
When consuming watermelon, it is recommended to do so in moderation. Overconsumption may burden the gastrointestinal tract, potentially leading to symptoms such as abdominal pain, diarrhea, and vomiting. Individuals with weak spleen and stomach function, cold stomach, or poor gastrointestinal health should consume watermelon moderately or avoid it altogether.