Can Metformin Extended-Release Tablets be chewed?

Metformin hydrochloride sustained-release tablets, also known as metformin hydrochloride extended-release tablets. Under normal circumstances, metformin hydrochloride sustained-release tablets should not be chewed. If usage is required, it is recommended to consult a physician. Detailed analysis is as follows:

Metformin hydrochloride sustained-release tablets are designed to slowly release the active drug component, maintaining a stable drug concentration in the body to achieve continuous blood glucose reduction. Chewing the sustained-release tablets will disrupt the slow-release mechanism, causing rapid drug release, which may lead to a sudden drop in blood glucose levels and trigger adverse reactions such as hypoglycemia. Additionally, chewing the tablets may result in inaccurate dosing, affecting treatment efficacy.

Chewing metformin hydrochloride sustained-release tablets may also increase gastrointestinal irritation. The sustained-release formulation is specifically designed to reduce direct gastrointestinal irritation and protect the gastrointestinal mucosa. Once chewed, the drug particles come into direct contact with the gastrointestinal mucosa, potentially causing discomfort symptoms such as abdominal pain, diarrhea, nausea, and vomiting, thereby affecting the patient's comfort and quality of life.

In daily life, attention should be paid to the timing of medication. It is generally recommended to take the medication with or after meals to reduce gastrointestinal irritation.