Nitroglycerin tablets can relieve headaches during sleep.
Generally, if headaches occurring during sleep are caused by coronary artery spasm, nitroglycerin tablets can usually relieve them. However, if the headaches are common primary headaches, nitroglycerin tablets typically cannot provide relief. Detailed explanation is as follows:

If headaches during sleep are caused by variant angina (such as coronary artery spasm) radiating to the head, nitroglycerin tablets may help alleviate the headache. Nitroglycerin tablets can dilate the coronary arteries, increase myocardial blood supply, and relieve coronary artery spasm, thereby reducing referred headaches caused by cardiac issues.
If the headaches are common primary headaches such as migraine or tension-type headache, nitroglycerin tablets usually cannot relieve them. The pathogenesis of migraine is mainly related to abnormal cerebral vascular constriction and dilation and neurotransmitter dysfunction, while tension-type headaches are often associated with muscle tension in the head and neck regions. Nitroglycerin tablets are not effective against these underlying causes.
For the management of headaches during sleep, it is recommended to identify and eliminate possible causes, such as improving the sleep environment and adjusting sleeping posture. If headaches persist or worsen, timely medical consultation is advised so that doctors can formulate appropriate treatment plans based on individual conditions.