Can Rabeprazole treat gastric erosion?

Feb 17, 2025 Source: Cainiu Health

Dr. Shen Yonghua

Introduction

If gastric erosion is caused by excessive gastric acid secretion, the excess acid can erode the gastric mucosa and lead to the condition. As a proton pump inhibitor, Rabeprazole acts on the parietal cells of the gastric mucosa, effectively reducing gastric acid secretion by inhibiting proton pump activity, thereby decreasing the irritation of gastric acid on the eroded areas of the stomach and creating favorable conditions for the repair of the gastric mucosa.

Generally, common formulations of rebamipide include tablets, capsules, and injections. If gastric erosion is caused by excessive gastric acid secretion, rebamipide is usually effective. However, if the gastric erosion is caused by drug-induced gastric injury and the causative drug has not been discontinued, rebamipide alone is typically not sufficient for treatment. Detailed explanations are as follows:

If gastric erosion is caused by excessive gastric acid secretion, the excess acid can erode the gastric mucosa and lead to damage. As a proton pump inhibitor, rebamipide acts on the parietal cells of the gastric mucosa, effectively reducing gastric acid secretion by inhibiting proton pump activity, thereby decreasing irritation to the eroded areas of the stomach and creating favorable conditions for the repair of gastric mucosa.

If gastric erosion is caused by drug-induced gastric injury and the causative drug continues to be used, treatment with rebamipide alone may not be sufficient. For drug-induced gastric injury, it is necessary to discontinue the related medication and implement comprehensive treatment measures. Autoimmune gastritis may also require treatment targeting immune abnormalities, such as the use of immunosuppressive agents.

During the treatment of gastric erosion, patients are advised to avoid consuming spicy and irritating foods, as well as alcohol and tobacco, to minimize further damage to the gastric mucosa. At the same time, maintaining healthy lifestyle habits can help promote gastric health.

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