Can CIN3 with glandular involvement be completely cured without recurrence?

Generally, if the lesion is completely removed and the surgical margins are negative, the risk of recurrence is relatively low. If the surgical margins are positive or there is residual lesion, the risk of recurrence typically increases. However, the specific details are as follows:

If the lesion is completely removed and the pathology report indicates negative margins (i.e., no residual lesion at the edge of the excised tissue), the risk of recurrence is usually low. However, if the surgical margins are positive or there is residual lesion, meaning that lesion cells or tissues remain at the edge of the excised tissue, the risk of recurrence will correspondingly increase.

Cervical conization aims to remove the lesion while preserving fertility. If the surgery is successful and postoperative care is properly managed, the risk of recurrence remains low. For patients without fertility requirements or those with more severe disease, a hysterectomy may be more appropriate. After hysterectomy, since the cervix no longer exists, the risk of recurrence of CIN3 with glandular involvement theoretically drops to zero; however, the possibility of vaginal intraepithelial neoplasia should still be considered.

Postoperatively, patients should follow medical advice regarding medication, ensure adequate sleep, avoid staying up late, and attend regular follow-up appointments at the hospital. These measures can help reduce the risk of recurrence. Even if the surgery is successful and proper postoperative care is provided, regular follow-up examinations are still necessary. Follow-up visits allow for early detection and management of any potential issues.