What is rickets?
Generally, rickets is a systemic, chronic, nutritional disease characterized by skeletal lesions. It mainly occurs due to vitamin D deficiency in infants, children, and adolescents, which causes disturbances in calcium and phosphorus metabolism, leading to a systemic, chronic, nutritional disease marked by skeletal abnormalities. A detailed explanation is as follows:
When vitamin D is deficient, absorption of calcium and phosphorus from the intestines decreases, leading to reduced blood calcium and phosphorus levels. The drop in blood calcium stimulates the parathyroid glands to secrete parathyroid hormone (PTH), which enhances the activity of osteoclasts, accelerating the dissolution of bone salts and releasing calcium and phosphorus into the bloodstream to maintain normal or near-normal blood calcium levels. However, PTH also inhibits the renal tubules' reabsorption of phosphorus, increasing urinary phosphorus excretion and lowering blood phosphorus levels, thereby decreasing the calcium-phosphorus product. This affects the calcification of osteoid tissue, leading to bone softening and skeletal deformities.
Clinical manifestations of rickets mainly include skeletal changes, muscle hypotonia, and non-specific mental and neurological symptoms. Skeletal changes may present as pigeon chest, funnel chest, scoliosis, bowlegs (O-shaped legs), or knock knees (X-shaped legs). Muscle hypotonia manifests as delayed development of motor skills such as lifting the head, sitting, standing, and walking. Mental and neurological symptoms include irritability, easy agitation, restless sleep at night, and excessive sweating.
In daily life, it is important to increase outdoor activities and sun exposure, as 7-dehydrocholesterol in the skin can be converted into vitamin D under the ultraviolet rays of sunlight, which is an important way for the human body to obtain vitamin D. It is recommended to spend at least two hours outdoors daily. A balanced diet should also be ensured. Infants should be breastfed when possible, and complementary foods rich in vitamin D, calcium, and phosphorus, such as animal liver, egg yolks, and dairy products, should be introduced timely.