What does "closed antibody" mean?
Mar 17, 2025
Source: Cainiu Health
Dr. Zhang Lu
Introduction
During a normal pregnancy, blocking antibodies can bind to antigens on the surface of embryonic trophoblast cells. They can prevent the maternal immune system from mounting an immune attack against the embryo, thereby providing a protective effect for the embryo. To the maternal immune system, the embryo is recognized as a foreign graft, and the immune system will instinctively generate a rejection response against it.
Under normal circumstances, blocking antibodies are a type of antibody present in the serum of healthy pregnant women. A detailed analysis is as follows:
Blocking antibody is a specific IgG antibody against paternal lymphocytes present in the serum of normal pregnant women. It can bind to antigens on the surface of embryonic trophoblast cells. Blocking antibodies can prevent the maternal immune system from attacking the embryo. If a pregnant woman lacks sufficient blocking antibodies, her body may mount a strong immune rejection response against the fetus, potentially leading to recurrent spontaneous abortion in early pregnancy, and in late pregnancy, conditions such as gestational hypertension, intrauterine fetal growth restriction, and others may occur. For patients experiencing recurrent spontaneous abortions, testing for blocking antibodies is highly necessary.
Maintaining good lifestyle habits and avoiding excessive fatigue and mental stress are important. It is recommended to arrange work and rest time reasonably, and to relieve stress through appropriate exercise, meditation, and other methods.
