What are the side effects and risks of taking Oryzanol?

　　Normally, the dosage forms of Oryzanol include tablets, injection solutions, etc. Its side effects and harms include gastrointestinal discomfort, abnormal sebum secretion, weight gain, breast tenderness, hair loss, etc. It is recommended to use the medication as directed by a physician. The specific analysis is as follows:

　　1. Gastrointestinal discomfort

　　Oryzanol may alter the mucus barrier function of the gastric mucosa surface, making the gastric mucosa more susceptible to irritation from gastric acid and other digestive fluids. This affects the normal peristalsis of gastric smooth muscle and interferes with the secretion and function of digestive enzymes, ultimately leading to nausea, vomiting, and other discomfort symptoms in the stomach.

　　2. Abnormal sebum secretion

　　Oryzanol might interfere with the signal transduction pathways within sebaceous gland cells, promoting excessive activity of the sebaceous glands, increasing sebum synthesis and secretion. Conversely, reduced sebum secretion could be due to the drug affecting the synthesis and metabolism of intercellular lipids in the skin, leading to decreased skin moisturization and resulting in dryness, roughness, and flaking of the skin.

　　3. Weight gain

　　Oryzanol may act on the body's endocrine regulatory center, affecting the secretion and activity of hormones closely related to metabolism, such as thyroid hormones, thereby lowering the body's basal metabolic rate and reducing energy expenditure. At the same time, it may also promote glucose uptake by fat cells, accelerating fat synthesis, which together lead to weight gain.

　　4. Breast tenderness

　　Oryzanol may affect the regulatory function of the hypothalamic-pituitary-gonadal axis, causing an imbalance in the relative proportions of estrogen and progesterone. When estrogen levels are relatively elevated or progesterone levels are relatively decreased, breast tissue is overstimulated, causing breast tenderness. Around the menstrual cycle, when hormone levels are naturally fluctuating, the sensation of tenderness becomes more pronounced.

　　5. Hair loss

　　The hair follicle growth cycle is regulated by multiple factors. Oryzanol may interfere with the proliferation and differentiation processes of hair follicle stem cells, affecting the balance of cytokines and growth factors in the hair follicle microenvironment, causing the hair follicles to enter the telogen phase prematurely. This leads to synchronized shedding of a large amount of hair, disrupting the normal cycle of hair growth and shedding, resulting in increased hair loss.

　　When taking Oryzanol, it is essential to strictly follow the physician's advice and prescription for medication use. Do not blindly increase the dose or prolong the duration of medication on your own. If you experience any of the aforementioned adverse symptoms, stop the medication promptly and seek medical attention as soon as possible to take appropriate measures for management.