Which health conditions are not suitable for in vitro fertilization (IVF)?

Generally, in vitro fertilization (IVF) refers to the process of in vitro fertilization combined with embryo transfer. IVF-embryo transfer is not suitable for individuals with severe reproductive system abnormalities, uncontrolled severe systemic diseases, acute infectious diseases, severe mental disorders, or malignant tumors. Detailed explanations are as follows:

　　1. Severe reproductive system abnormalities

　　Conditions such as congenital absence of the uterus or rudimentary uterus result in severely abnormal uterine shape or structure. Patients with such conditions lack the basic requirements for fetal development; even if embryos are implanted, normal implantation and development are unlikely.

　　2. Uncontrolled severe systemic diseases

　　Severe heart disease, uncontrolled hypertension, severe kidney disease, and similar conditions increase the burden on organs such as the heart and kidneys during pregnancy, potentially worsening the condition and endangering the patient's life. These conditions are also detrimental to fetal development and may lead to complications such as preterm birth or fetal growth restriction.

　　3. Acute infectious diseases

　　During the active phase of infectious diseases such as acute pelvic inflammatory disease, acute hepatitis, or HIV/AIDS, the patient's body is in an inflammatory state. Performing IVF-embryo transfer may cause the inflammation to spread, interfere with embryo implantation and development, and potentially transmit pathogens to the fetus.

　　4. Severe mental disorders

　　Patients with severe depression, schizophrenia, or other serious mental disorders may be unable to cooperate with the procedures and examinations involved in IVF-embryo transfer. Moreover, the physiological and psychological stress of pregnancy and childbirth may exacerbate mental health symptoms, posing significant risks to both maternal and fetal well-being.

　　5. Malignant tumors

　　Whether the tumor is located in the reproductive system (e.g., ovarian cancer, endometrial cancer) or elsewhere in the body, patients typically require comprehensive treatment including surgery, radiotherapy, and chemotherapy. These treatments can severely affect the embryo, and pregnancy itself may promote tumor growth and metastasis, negatively impacting the patient's prognosis.

　　Before considering IVF-embryo transfer, it is recommended to consult a professional physician or reproductive specialist and undergo comprehensive physical examinations and evaluations to determine whether this treatment is appropriate.