Can I take Metformin Extended-Release Tablets while trying to conceive?

Metformin hydrochloride sustained-release tablets, also known as metformin hydrochloride extended-release tablets, generally can be taken in appropriate amounts during the preconception period if used under medical guidance. However, this medication should not be taken in cases of impaired liver or kidney function or if the medication is not taken as directed. If there are any concerns, it is recommended to consult a healthcare provider in advance. Detailed explanation is as follows:

Metformin hydrochloride sustained-release tablets are an antidiabetic medication primarily used in the treatment of type 2 diabetes. Patients with high blood glucose levels who are planning to conceive should control their blood sugar within the normal range and may take metformin hydrochloride sustained-release tablets in appropriate amounts under a doctor's supervision. This medication does not have significant adverse effects on the reproductive system nor does it cause endocrine disorders, and generally does not negatively affect preconception efforts.

However, the drug is metabolized and excreted through the liver and kidneys, and patients with impaired liver or kidney function may experience worsening of their condition if they take this medication. Additionally, if the medication is not taken as directed by a physician—such as taking excessive doses or long-term high-dose usage—it may lead to adverse reactions such as gastrointestinal symptoms like nausea and vomiting. In severe cases, it may even cause lactic acidosis, which can lead to liver and kidney dysfunction. These adverse effects may impact the success rate of conception and pose risks to fetal health.

During the preconception period, patients taking metformin hydrochloride sustained-release tablets should strictly follow medical instructions and undergo regular physical examinations and blood glucose monitoring to ensure their health is suitable for pregnancy. Once pregnancy is confirmed, the medication should be discontinued immediately and a hospital visit should be made to assess fetal development.