How many days does jaundice affect the brain?
Jul 08, 2025
Source: Cainiu Health
Dr. Shen Yonghua
Introduction
Children with underlying conditions such as preterm birth or infection have weaker metabolic capacity for bilirubin, and their jaundice may last longer. Typically, within 5 to 7 days, jaundice could potentially affect the brain. The blood-brain barrier in these children is not fully developed, allowing bilirubin to accumulate in the body and enter the brain more easily. Once bilirubin accumulates to a certain level over a relatively short period, it can cause damage.
Generally, if jaundice persists beyond 3 to 7 days, it may affect the brain. If there are any concerns, it is recommended to seek medical advice earlier. Detailed analysis is as follows:
Children with underlying conditions such as prematurity or infections have weaker metabolic capacity for bilirubin, and their jaundice may last longer. In such cases, brain function could be affected within 5 to 7 days. These children have an underdeveloped blood-brain barrier, allowing bilirubin to accumulate in the body and enter the brain more easily, causing damage once a certain level has been reached.
Full-term infants with good overall health have relatively stronger metabolic functions. Jaundice of short duration generally does not affect the brain, and brain damage typically does not occur within 3 to 4 days. Their blood-brain barrier is more fully developed and provides better protection against bilirubin, making it difficult for bilirubin to cross the barrier and interfere with brain function in a short time.
During the period of persistent jaundice, close monitoring of bilirubin levels is necessary. If jaundice exceeds the aforementioned time ranges, prompt medical evaluation and intervention are required to prevent brain damage.
