What does a high-risk result in Down syndrome screening mean?

Generally, a high-risk result from Down syndrome screening indicates that during prenatal screening for Down syndrome, the test results suggest a higher likelihood that the fetus has Down syndrome. Detailed explanation is as follows:

Down syndrome screening calculates the risk probability of the fetus having Down syndrome and other chromosomal disorders by analyzing specific biomarkers in the mother's serum, such as alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol, along with factors like the mother's age and gestational age, using specific algorithms. This is a prenatal screening test designed to help identify fetuses that may be at risk for chromosomal abnormalities. A high-risk result means the probability of the fetus having Down syndrome or other chromosomal abnormalities is relatively higher, but this does not equate to a definitive diagnosis. In fact, only some fetuses of mothers with high-risk results are ultimately diagnosed with chromosomal abnormalities.

A high-risk result from Down syndrome screening may cause significant psychological stress to the pregnant woman. Therefore, support from family members and healthcare providers is particularly important. The pregnant woman should maintain a positive mindset and cooperate with further examinations and treatments. Healthcare providers can offer psychological counseling to help alleviate anxiety. Additionally, the pregnant woman can seek support from family, friends, or professional psychological services, and participate in relevant support groups to share feelings and relieve stress.