Breast cancer p63 negative, is it serious?

Generally, breast cancer P63 shows a negative result, meaning breast cancer P63 (-), which usually indicates P63 negativity and may suggest the presence of breast cancer. If the cancer is at an early stage and the cancer cells have not yet spread extensively, the condition is usually not severe. However, if it is already at an advanced stage with cancer cell metastasis, the situation becomes serious. If discomfort symptoms arise, timely consultation at a reputable hospital is recommended. Detailed explanation is as follows:

In cases of breast cancer P63 (-) at an early stage where the cancer cells have not yet spread widely, the condition is generally not severe. During the early phase of breast cancer, the tumor is often confined to its original location without invading surrounding tissues or distant metastasis. The P63 negative marker primarily serves as an auxiliary indicator for determining tumor pathology type. At this stage, with active treatment such as surgical removal of the lesion, most patients can achieve favorable outcomes. The risks of postoperative recurrence and metastasis are relatively low, survival duration can be effectively prolonged, and quality of life remains minimally affected.

Conversely, when breast cancer P63 (-) is at an advanced stage and cancer cells have already spread, the condition becomes more severe. Advanced breast cancer indicates that cancer cells may have metastasized to distant organs such as the lungs, liver, or bones, causing damage to multiple body systems and increasing treatment difficulty. In this context, P63 negativity might indicate certain specific biological characteristics of the tumor that could influence treatment options and efficacy. Patients may require comprehensive treatment approaches including chemotherapy, radiotherapy, targeted therapy, among others. However, recurrence rates after treatment are high, patient survival may be significantly affected, and quality of life can greatly decline.

Once breast cancer is diagnosed, patients should promptly cooperate with their doctors for treatment. Treatment plans need to comprehensively consider factors such as the patient's physical condition, tumor characteristics, pathological stage, and other relevant elements.