Can foot numbness caused by linezolid side effects be recovered?

Under normal circumstances, linezolid is commonly administered in tablet and injectable forms. Foot numbness caused by linezolid is generally reversible, although the extent and duration of recovery depend on the length of drug exposure and the severity of nerve damage. Detailed explanation is as follows:

The neurotoxicity of linezolid is associated with treatment duration. Long-term or high-dose usage can easily lead to peripheral neuropathy, manifested as limb numbness, tingling sensations, more commonly affecting the lower extremities. The mechanism may be related to the inhibition of mitochondrial protein synthesis. If the medication is discontinued promptly at the early stage of symptom onset, mild cases usually experience gradual improvement within weeks to months. However, if treatment continues and nerve axon damage worsens, recovery may be delayed, typically requiring several months to over a year. In some severe cases, partial sensory abnormalities may persist.

Upon experiencing foot numbness, patients should seek immediate medical evaluation. Under a physician's guidance, discontinuation or adjustment of the medication regimen may be considered. Additionally, supplementation with B-complex vitamins may aid in nerve repair. It is important not to discontinue the medication without medical advice, as this may compromise infection control.