Can cephalosporin antibiotics be taken while eating durian?

Aug 05, 2025 Source: Cainiu Health

Dr. Shen Yonghua

Introduction

If you have just eaten durian and then take cephalosporin antibiotics, the components in durian may affect drug metabolism and increase the risk of adverse reactions, such as palpitations and nausea. In such cases, they should not be consumed together, and it is necessary to avoid contact between the two within a short period. If at least 72 hours have passed after eating durian, and there is no history of allergy to either durian or cephalosporin antibiotics, then it may be safe to proceed.

Generally speaking, it is not recommended to take cephalosporin antibiotics immediately after consuming durian. However, if a sufficient amount of time has passed and there are no unusual bodily reactions, it may be possible to take cephalosporins under a doctor's guidance. Detailed explanations are as follows:

If cephalosporin antibiotics are taken immediately after eating durian, components in the durian may interfere with drug metabolism and increase the risk of adverse reactions, such as palpitations and nausea. In this case, taking both together is not advised, and contact between the two should be avoided within a short timeframe.

If at least 72 hours have passed since durian consumption, and there is no history of allergy to durian or cephalosporin antibiotics, it may be possible to take the medication after evaluation by a doctor. At this point, the durian should have been largely metabolized, and its interference with the medication should be minimal. However, close attention should still be paid to bodily conditions.

During the period of taking cephalosporin antibiotics and around that time, strict control of the time interval between consumption of durian and other foods is necessary. If discomfort occurs after unintentional simultaneous exposure, discontinue use immediately and seek medical attention. Do not attempt to self-diagnose or delay treatment.

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