Is there a special risk associated with penicillin use in the elderly?

Aug 12, 2025 Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Elderly individuals experience a decline in bodily functions and reduced liver and kidney function, which may slow the metabolism and excretion of penicillin. This can lead to drug accumulation in the body, increasing the likelihood of adverse reactions such as dizziness and nausea, and may even加重 the burden on the kidneys. Elderly patients often have multiple underlying medical conditions and take various medications concurrently. Penicillin may interact with other drugs, affecting therapeutic efficacy or causing adverse effects.

Generally, there are some specific risks associated with the use of penicillin in elderly individuals, so extra caution is required. If there are any concerns, it is recommended to seek medical advice in advance. Detailed analysis is as follows:

As the body's functions decline with age, liver and kidney function may weaken, potentially slowing the metabolism and excretion of penicillin. This may lead to drug accumulation in the body, increasing the likelihood of adverse reactions such as dizziness, nausea, and even potentially加重 kidney burden.

Elderly individuals often have multiple underlying medical conditions and take various medications. Penicillin may interact with other drugs, affecting efficacy or causing discomfort. Moreover, elderly patients may have a delayed perception and expression of allergic reactions, making it difficult to detect symptoms such as rash or difficulty breathing in a timely manner, which could delay treatment.

When using penicillin, elderly patients must strictly inform their doctor about their health status and medication history. Close monitoring of physical reactions is necessary during treatment, and any discomfort should be immediately reported to medical personnel.