What are the differences between hs-CRP and CRP?

　　Hs-CRP and CRP are essentially the same protein, with the main differences体现在检测灵敏度, detection range, clinical application scenarios, applicable populations, and testing purposes. A detailed analysis is as follows:

　　1. Detection Sensitivity: Hs-CRP, or high-sensitivity C-reactive protein, utilizes high-sensitivity detection technology capable of accurately measuring low concentration levels (typically as low as 0.1mg/L) of the protein. In contrast, conventional CRP testing methods have lower sensitivity and are primarily designed for detecting higher concentration levels (usually starting from 10mg/L).

　　2. Detection Range: Hs-CRP has a narrower detection range, typically concentrated between 0.1-10mg/L, making it suitable for detecting changes at low concentration levels. CRP has a broader detection range, generally covering 0-100mg/L or even higher, which meets the needs of detecting moderate to high concentration levels.

　　3. Clinical Application Scenarios: Hs-CRP is primarily used to assess chronic inflammatory states, whereas CRP is mainly used to determine acute infections, acute inflammation, or tissue damage.

　　4. Applicable Populations: Hs-CRP is more suitable for healthy individuals or those at high risk for chronic diseases—for example, cardiovascular risk assessment in middle-aged and elderly populations or inflammation monitoring in diabetic patients. CRP is more appropriate for individuals experiencing acute symptoms such as fever, localized redness, swelling, and pain.

　　5. Testing Purposes: The purpose of Hs-CRP testing is to detect mild, chronic inflammation and provide evidence for early disease prevention and risk assessment. CRP testing aims to rapidly identify acute, moderate to severe inflammation or infection, providing reference for disease diagnosis and monitoring treatment effectiveness.

　　The choice between Hs-CRP and CRP testing should be based on specific health needs and symptom presentation. CRP testing is preferred in cases of acute discomfort, while Hs-CRP testing may be considered for chronic disease risk screening or health assessment.