Which medication can treat headaches upon waking up?

Generally, headaches after waking up are often related to poor sleep quality, cerebral vascular spasm, muscle tension, and other factors. They are commonly seen in conditions such as tension-type headaches and migraine. Patients can follow medical advice to use medications such as ibuprofen sustained-release tablets, acetaminophen tablets, naproxen sodium tablets, zolmitriptan tablets, and compound aspirin tablets for treatment. Detailed explanations are as follows:

1. Ibuprofen Sustained-Release Tablets

Ibuprofen belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) and alleviates inflammation and nerve stimulation by inhibiting prostaglandin synthesis, thus relieving headache symptoms. The sustained-release formulation can provide effects for 12 hours and is suitable for persistent headaches after waking up, especially effective for tension-type headaches accompanied by mild inflammation.

2. Acetaminophen Tablets

Acetaminophen exerts antipyretic and analgesic effects by inhibiting prostaglandin synthesis in the central nervous system. It causes less gastrointestinal irritation and is suitable for mild to moderate headaches after waking up, particularly appropriate for individuals intolerant to NSAIDs, such as those with sensitive gastrointestinal systems.

3. Naproxen Sodium Tablets

Naproxen sodium inhibits cyclooxygenase activity, reducing prostaglandin production. It has strong analgesic and anti-inflammatory effects, lasting 8–12 hours. It effectively relieves headaches after waking caused by muscle tension or migraine and is suitable for more pronounced headache symptoms.

4. Zolmitriptan Tablets

Zolmitriptan belongs to the triptan class of medications. It activates serotonin receptors, constricts cerebral blood vessels, and inhibits neuropeptide release, rapidly alleviating migraines. It is suitable for patients diagnosed with migraine after waking up and effectively reduces pulsating headaches and associated nausea.

5. Compound Aspirin Tablets

Compound aspirin tablets consist of aspirin, phenacetin, and caffeine. Aspirin and phenacetin inhibit prostaglandin synthesis, while caffeine constricts cerebral blood vessels and enhances analgesic effects. These tablets are suitable for headaches caused by cerebral vascular dilation after waking up, especially effective for tension-type headaches accompanied by fatigue.

In daily life, maintaining regular sleep patterns, avoiding staying up late or oversleeping, choosing appropriate pillows to maintain cervical spine comfort, and reducing neck muscle tension are recommended. Avoid drinking coffee or strong tea before bedtime, manage anxiety, create a quiet sleeping environment, and reduce the likelihood of headaches upon waking.