Can Hepatitis B 'small three positives' turn negative?

Generally, whether HBV small three positives can become negative mainly depends on multiple factors, including viral load, liver function status, immune system condition, and whether appropriate treatment is received. If discomfort symptoms occur, timely consultation and treatment at a regular hospital are recommended. Detailed analysis is as follows:

If patients with HBV small three positives do not receive standardized treatment but have low viral load, continuously normal liver function, and good immune system function, spontaneous seroconversion may occur in some cases. This situation mostly relies on the body's immune system to clear the virus naturally. However, the probability of seroconversion is relatively low, and long-term monitoring of viral load and liver function changes is necessary to avoid silent disease progression.

If patients with HBV small three positives have high viral load, abnormal liver function, or an immune system unable to effectively control the virus, timely standardized treatment can increase the probability of seroconversion. Regular follow-up examinations are required during treatment, with therapeutic regimens adjusted according to viral load and liver function indicators, helping to suppress viral replication, promote immune clearance of the virus, and gradually achieve the goal of seroconversion.

Daily lifestyle should emphasize regular作息, avoiding excessive fatigue and alcohol consumption to reduce the burden on the liver. Consistent follow-up examinations should be maintained, including viral load testing and liver function assessments, to monitor disease progression promptly. Professional guidance must be followed; indiscriminate use of unverified remedies should be avoided, ensuring scientifically sound treatment and care to support disease stabilization and recovery.