Can hepatitis B 'small three positives' be transmitted between spouses?

Sep 03, 2025 Source: Cainiu Health
Dr. Gao Jun
Introduction
HBV small three positives refers to a situation in the five-serum marker test for hepatitis B where the hepatitis B surface antigen (HBsAg), hepatitis B e antibody (HBeAb), and hepatitis B core antibody (HBcAb) are positive, while the other two markers are negative. Generally, transmission between spouses may occur in such cases. The uninfected partner should regularly monitor their hepatitis B antibody levels and receive hepatitis B vaccination or booster shots if the antibody titer is insufficient. Protective measures can also be taken during sexual activity, according to a physician's recommendation.

  HBV minor triple-positive refers to testing positive for three items in the standard five-item hepatitis B test: hepatitis B surface antigen, hepatitis B e antibody, and hepatitis B core antibody, while the other two items are negative. Generally speaking, transmission between spouses may occur at this time. Detailed analysis is as follows:

  Hepatitis B virus (HBV) is mainly transmitted through blood and bodily fluids. For example, during sexual activity, if proper protection is not used, the virus may enter the other partner's body through mucosal contact when the viral load of one partner is high. Additionally, sharing personal items that may come into contact with blood, such as toothbrushes and razors, can also lead to transmission if one person has skin injuries. However, the probability of transmission is not absolute; if the uninfected partner has sufficient hepatitis B antibodies, they can effectively resist viral invasion and reduce the risk of infection.

  The uninfected partner should regularly monitor their hepatitis B antibody levels. If antibody titers are insufficient, timely vaccination or booster doses of the hepatitis B vaccine should be administered. Protective measures during sexual activity can be adopted according to medical advice to reduce the possibility of viral transmission. Both partners should avoid sharing personal items such as toothbrushes and razors to prevent indirect contact transmission. The infected partner should undergo regular monitoring of viral load and liver function, and if the virus is active, standardized treatment should be implemented to reduce infectivity and protect the partner's health.