Which medications should not be taken with shrimp?

Generally, shrimp should not be consumed with certain medications such as Levofloxacin Hydrochloride Tablets, Cefoperazone Sodium and Sulbactam Sodium Injection, Furazolidone Tablets, Compound Sulfamethoxazole Tablets, or Vitamin C Tablets. The specific explanations are as follows:

1. Levofloxacin Hydrochloride Tablets

Levofloxacin Hydrochloride belongs to the quinolone class of antibiotics. Shrimp contains abundant minerals such as calcium and magnesium. When taken together, these minerals may bind with the medication to form complexes that are difficult to absorb, reducing the drug's absorption efficiency in the body. This may compromise its antibacterial effectiveness, making it less effective in eliminating pathogenic bacteria and hindering the treatment of infectious diseases.

2. Cefoperazone Sodium and Sulbactam Sodium Injection

Cefoperazone Sodium Sulbactam Sodium belongs to the cephalosporin class of antibiotics and contains a methylthiotetrazole side chain. Shrimp is a high-protein food that may produce small amounts of tyramine during metabolism in the body. This medication can inhibit tyramine metabolism by reducing the activity of tyramine-metabolizing enzymes, leading to tyramine accumulation. This may cause adverse reactions such as facial flushing, headache, nausea, palpitations, and other discomforts.

3. Furazolidone Tablets

Furazolidone is a nitrofuran-class antimicrobial agent. Shrimp naturally contains a certain amount of histamine. This medication inhibits histamine-degrading enzymes, preventing the breakdown of histamine from shrimp and histamine produced during metabolism in the body. Accumulation of histamine may lead to histamine poisoning, causing symptoms such as skin itching, swelling, difficulty breathing, abdominal pain, and vomiting.

4. Compound Sulfamethoxazole Tablets

Compound Sulfamethoxazole Tablets contain sulfamethoxazole and trimethoprim and belong to the sulfonamide class of combination antibiotics. Shrimp is a high-purine food, and sulfonamide drugs may affect uric acid excretion. When taken together, they can further impair the excretion of uric acid, leading to elevated levels of uric acid in the body.

5. Vitamin C Tablets

Shrimp contains pentavalent arsenic compounds, and Vitamin C has reducing properties. When taken together, Vitamin C may reduce pentavalent arsenic in shrimp to toxic trivalent arsenic. Long-term or excessive simultaneous consumption may lead to gradual accumulation of trivalent arsenic in the body, increasing the risk of poisoning and potentially causing damage to organs such as the liver and kidneys.

During medication, it is important to maintain a light diet. In addition to avoiding shrimp, other high-purine seafood should also be avoided when taking the above medications. Carefully read the drug's instructions before use to understand dietary restrictions. If shrimp is accidentally consumed during treatment and adverse symptoms occur, seek medical attention promptly.