39℃, what should I do if my fever doesn't subside after taking ibuprofen?

Sep 11, 2025 Source: Cainiu Health
Dr. Wang Lei
Introduction
In general, if a fever of 39 °C does not subside after taking ibuprofen, it may be due to insufficient medication time, inadequate water intake, insufficient drug dosage, bacterial infection, or worsening of a viral infection. It is recommended to seek timely medical attention, identify the underlying cause, and then improve the condition through general treatment, medication, and other approaches under a doctor's guidance. In daily life, maintain good indoor ventilation and keep the room temperature between 24-26 °C.

Generally, if a fever of 39°C does not subside after taking ibuprofen, it may be due to insufficient medication time, inadequate water intake, insufficient drug dosage, bacterial infection, worsening viral infection, or other reasons. It is recommended to seek medical attention promptly, identify the cause, and improve the condition through general treatment, medication, and other methods under a doctor's guidance. Detailed analysis is as follows:

1. Insufficient medication time: Ibuprofen typically starts to take effect 30 minutes to 1 hour after administration. If the time since taking the medication is too short, body temperature may not have started to decrease yet. Be patient and wait for the medication to take effect; avoid frequently adding additional doses. Rest in bed to reduce physical exertion.

2. Inadequate water intake: Dehydration can affect sweat secretion and evaporation, hindering heat dissipation and reducing the effectiveness of fever reduction. Immediately increase water intake, drinking 100-150 ml of warm water each time, with a total daily intake of 1500-2000 ml to promote sweating and assist fever reduction.

3. Insufficient drug dosage: Not taking an adequate dose of ibuprofen according to body weight or age may prevent effective inhibition of prostaglandin synthesis, thus affecting fever reduction. Under a doctor's guidance, consider switching to other medications such as acetaminophen tablets, diclofenac sodium sustained-release tablets, or loxoprofen sodium tablets, which can be alternated to enhance fever-lowering effects.

4. Bacterial infection: Conditions such as bacterial tonsillitis or pneumonia involve toxins continuously released by bacteria that stimulate the body, making it difficult for ibuprofen alone to reduce the fever. Patients should follow medical advice to use anti-infective medications such as amoxicillin capsules, cefuroxime axetil tablets, or levofloxacin tablets to control inflammation at its source and alleviate fever symptoms.

5. Worsening viral infection: For example, with worsening influenza or coronavirus infection, extensive viral replication triggers a strong immune response, leading to persistent high fever. Follow medical advice to use antiviral medications such as oseltamivir capsules, arbidol tablets, or Lianhua Qingwen capsules to inhibit viral replication.

In daily life, maintain indoor ventilation and keep room temperature between 24-26°C to avoid excessive environmental heat affecting heat dissipation. Follow a light and easily digestible diet, consuming more porridge, noodles, and other foods to replenish energy. Closely monitor body temperature changes, record fluctuations, and provide reference information for doctors adjusting treatment plans.