What are the effects of taking too much ibuprofen?

Generally, an overdose of ibuprofen may cause various adverse effects on the body, mainly including gastrointestinal damage, liver injury, kidney damage, neurological abnormalities, and cardiovascular discomfort. A detailed explanation is as follows:

1. Gastrointestinal Damage: Excessive ibuprofen irritates the gastric mucosa and disrupts the gastric mucosal barrier, possibly causing symptoms such as stomach pain, nausea, and vomiting. Severe cases may lead to mucosal erosion, ulcers, and even gastrointestinal bleeding, presenting as hematemesis or black stools.

2. Liver Injury: Ibuprofen is metabolized in the liver, and excessive intake increases the liver's metabolic burden, potentially damaging liver cells and causing abnormal liver function. Some individuals may experience fatigue, reduced appetite, yellowing of the skin or eyes (jaundice), and other symptoms.

3. Kidney Damage: Ibuprofen affects renal blood perfusion, and overdose intensifies this effect, possibly leading to decreased kidney function. Early signs may include reduced urine output and darker urine color. Severe cases can result in acute kidney injury.

4. Neurological Abnormalities: Overdose of ibuprofen may interfere with normal nervous system function, causing symptoms such as dizziness, headache, and drowsiness. Some individuals may experience agitation, confusion, and in severe cases, seizures or coma may occur.

5. Cardiovascular Discomfort: Excessive ibuprofen may affect the cardiovascular system, causing abnormal blood pressure fluctuations. Some individuals may experience palpitations and chest tightness. For those with pre-existing cardiovascular conditions, it may worsen the underlying disease.

When taking ibuprofen, strictly follow the instructions provided in the medication guide or by a physician to control the dosage. Avoid self-adjusting the dose or taking excessive amounts over a prolonged period. Also, monitor physical reactions, maintain a regular sleep schedule, follow a light diet, and minimize adverse drug effects on the body.