What does it mean if there's a painful lump in the armpit?

Oct 30, 2025 Source: Cainiu Health
Dr. Wang Lei
Introduction
A painful lump in the armpit may be caused by local friction, sweat blockage and infection, folliculitis, lymphadenitis, or sebaceous cysts. Symptoms can be improved by reducing friction, proper cleaning and care, medication, and local treatment. If the lump increases in size, pain worsens, or is accompanied by fever, prompt medical attention is necessary. Wearing tight clothing for prolonged periods can lead to repeated friction in the armpit area.

There may be a painful lump in the armpit due to local friction and irritation, blocked sweat glands with infection, folliculitis, lymphadenitis, or sebaceous cysts. Symptoms can be improved through reducing friction, proper cleaning and care, medication, and localized treatments. If the lump increases in size, pain worsens, or is accompanied by fever, prompt medical attention is necessary.

1. Local friction irritation: Wearing tight clothing over a long period can cause repeated rubbing in the armpit area, leading to thickened skin tissue and formation of a painful lump, especially noticeable during movement. It is recommended to switch to loose, soft cotton clothing to reduce friction in the armpit, avoid frequent pressure on the lump, and alleviate discomfort.

2. Blocked sweat and infection: In summer or after exercise, excessive sweating in the armpit may lead to blocked sweat glands if perspiration does not drain properly, increasing the risk of local infection and formation of a painful, red, swollen lump that might have a slight odor. It is advised to wash the armpits daily with warm water, keep the area dry, and wipe away sweat promptly to prevent prolonged moisture buildup.

3. Folliculitis: The armpit has dense hair growth; poor hygiene can promote bacterial growth, which may invade hair follicles and trigger inflammation. This results in red, painful lumps, sometimes accompanied by itching, and in severe cases, small white pus-filled spots may appear at the tip. Patients may use mupirocin ointment, fusidic acid cream, or cefuroxime axetil tablets under medical guidance to relieve symptoms.

4. Lymphadenitis: When there is an infection in the arm or chest, bacteria may spread to the armpit lymph nodes, causing them to swell and form a tender lump. Pain is obvious upon pressing, and the overlying skin may feel warmer. Under medical supervision, medications such as amoxicillin capsules, roxithromycin dispersible tablets, or ibuprofen sustained-release capsules may be used to manage symptoms.

5. Sebaceous cyst: Overactive sebaceous glands in the armpit may become obstructed, leading to cyst formation. If secondary infection occurs, a painful, red, swollen lump develops, possibly with discharge. Follow medical advice to use clindamycin gel, metronidazole gel, or levofloxacin capsules to improve symptoms.

Daily care should include keeping the armpit clean, avoiding scratching, using gentle cleansing products, wearing loose clothing to minimize irritation, monitoring changes in the lump, and seeking timely medical evaluation if abnormalities occur.