What are the efficacy and functions of nitrogen ketone?

Nitrogen mustard (Azone) offers several benefits and functions, including promoting drug penetration and absorption, enhancing the effectiveness of skincare ingredients, assisting in improving the efficacy of topical medications, increasing the utilization rate of cosmetic components, and facilitating the action of topical formulations. Detailed analysis is as follows:

1. Promoting drug penetration and absorption: Azone can alter the structure of the skin's stratum corneum and reduce the resistance to drug penetration, helping topical medications pass more effectively through the skin barrier into underlying tissues to exert their therapeutic effects. It is particularly effective in improving the local absorption efficiency of drugs that are otherwise difficult to penetrate the skin.

2. Enhancing the effectiveness of skincare ingredients: When added to skincare products, Azone promotes deeper penetration of active ingredients such as moisturizers and whitening agents into the skin, allowing them to interact more fully with skin cells. This enhances the product’s moisturizing, nourishing, and skin-improving effects while reducing waste of active components.

3. Assisting in improving topical medication efficacy: For topical formulations used to treat skin inflammation or pain, Azone helps deliver the active drug more quickly and deeply to the affected site. This shortens the onset time, increases drug concentration at the lesion, enhances local therapeutic effects, and aids in symptom relief.

4. Increasing cosmetic ingredient utilization: In cosmetics, Azone improves the adhesion and superficial penetration of ingredients such as sunscreens and coverage pigments. It reduces loss of these components from the skin surface, thereby prolonging the durability of sunscreen protection and cosmetic coverage, while minimizing heaviness caused by excessive residue on the skin.

5. Facilitating the effectiveness of topical formulations: Azone is commonly used as an excipient in topical preparations. While it does not directly exert pharmacological effects, it indirectly accelerates the onset and enhances the overall efficacy of the formulation by improving the permeability of drugs or active ingredients. It is thus a key auxiliary component in many topical products.

When using products containing Azone, check the ingredient list carefully. Individuals with sensitive skin should first conduct a patch test on a small area of skin to monitor for any adverse reactions such as redness, swelling, or itching.