What are the efficacy and effects of Fruquintinib capsules?

Generally, as an oral anti-angiogenic agent, fruquintinib capsules exert their effects primarily by inhibiting tumor angiogenesis, delaying tumor progression, improving the quality of life in patients with advanced cancer, reducing the size of certain tumor lesions, and enhancing therapeutic efficacy when used in combination therapies. The detailed analysis is as follows:

1. Inhibition of tumor angiogenesis: Fruquintinib capsules act on vascular endothelial cells within tumors, inhibiting the activity of vascular endothelial growth factor receptors (VEGFR), thereby reducing the formation of new blood vessels in tumors. When tumors are deprived of nutrients and oxygen supplied by new blood vessels, their growth rate significantly slows, suppressing tumor development at its source.

2. Delaying tumor progression: For cancers such as advanced metastatic colorectal cancer, this drug can block the blood supply to tumors, preventing further proliferation and spread of cancer cells. It prolongs the time to disease progression, helping patients maintain a relatively stable clinical condition and avoiding rapid deterioration in the short term.

3. Improving quality of life in patients with advanced cancer: While controlling tumor growth, fruquintinib capsules can reduce tumor-induced compression on surrounding tissues, alleviate symptoms such as pain and obstruction caused by tumor progression, decrease physical discomfort, help patients maintain certain daily activities, and thereby improve their overall quality of life.

4. Reducing the size of certain tumor lesions: In patients who are sensitive to the drug, some tumor lesions may shrink in volume due to nutrient deprivation following inhibition of angiogenesis, potentially achieving partial remission and creating more favorable conditions for subsequent treatments.

5. Enhancing efficacy through combination therapy: In specific cancer treatment regimens, this drug can be combined with chemotherapy or immunotherapy. By leveraging different mechanisms of action, it synergistically targets tumors, enhances overall treatment effectiveness, improves tumor control rates, and offers more treatment options for patients with advanced cancer.

Fruquintinib capsules must be used strictly according to medical instructions. Dosage should be adjusted based on the patient's condition and physical status. Potential adverse reactions should be closely monitored, and appropriate management measures taken promptly to ensure safe and effective treatment.