What should I do if I get reinfected with high-risk HPV after conization?

Re-infection with high-risk HPV after conization should be managed through comprehensive evaluation, immune enhancement, local medication, close follow-up monitoring, and, if necessary, secondary intervention. In most cases, the condition can be effectively controlled with standardized management, so there is no need for excessive anxiety. If cervical intraepithelial neoplasia or abnormal bleeding is detected, prompt medical attention is recommended.

1. Comprehensive Evaluation: Begin with cervical TCT and HPV genotyping tests to identify the specific HPV subtype and determine whether cervical cells are abnormal. Colposcopy may be performed when necessary to examine the cervix and assess for new lesions, providing a basis for further management.

2. Immune Enhancement: Improve immunity through regular sleep patterns, balanced nutrition, and moderate exercise. Under medical guidance, immune modulators may also be used to help the body clear the virus and reduce the risk of persistent infection.

3. Local Medication: If mild cervical lesions are present or viral load is high, follow doctor’s instructions to use topical antiviral or anti-inflammatory drugs. These help suppress viral replication, reduce cervical inflammation, and create favorable conditions for viral clearance. Medication must be strictly followed as prescribed.

4. Close Follow-up Monitoring: After surgery, HPV and TCT should be rechecked every 3–6 months to monitor viral clearance and changes in cervical cells. If persistent infection or cellular abnormalities are found, treatment plans should be adjusted promptly to prevent disease progression.

5. Secondary Intervention When Necessary: If follow-up reveals high-grade cervical intraepithelial neoplasia or new lesions caused by persistent viral infection, a second conization or other targeted treatments may be required after medical evaluation to completely remove diseased tissue and prevent progression to cervical cancer.

Maintain good personal hygiene, avoid unhygienic sexual practices to reduce the risk of viral transmission, maintain a positive mindset to minimize anxiety, and quit smoking or limit alcohol consumption to reduce adverse effects on immune function, thereby supporting viral clearance and recovery of cervical health.