What are the contraindications for taking Bicyclol tablets?

Bilicholic tablets, as a commonly used hepatoprotective agent, must be used strictly in accordance with contraindications, including allergy contraindications, special population restrictions, drug interaction precautions, disease suitability contraindications, and usage/dosage restrictions. A detailed analysis is as follows:

1. Allergy Contraindications: Bilicholic tablets are strictly prohibited for individuals allergic to any component of the drug or its excipients. Allergic reactions may manifest as skin itching, rash, difficulty breathing, and in severe cases, anaphylactic shock that could endanger life.

2. Special Population Contraindications: Pregnant and lactating women should not use this medication, as active ingredients may pass through the placenta or breast milk and affect normal fetal or infant development. Use in children is prohibited due to lack of supporting safety and efficacy data. Patients with severe liver failure should avoid this drug, as it may increase hepatic metabolic burden and worsen their condition.

3. Drug Interaction Precautions: Concurrent use with drugs known to have significant hepatotoxicity (e.g., certain antituberculosis or anticancer agents) is prohibited to avoid additive liver damage. Co-administration with traditional Chinese medicines or health supplements whose safety profiles are not well established is not recommended, as interactions may alter therapeutic effects or trigger adverse reactions.

4. Disease Suitability Contraindications: The drug is contraindicated in patients without confirmed evidence of liver function impairment, as unnecessary use may increase hepatic metabolic stress. In cases of liver dysfunction caused by viral infections or autoimmune diseases, bilicholic tablets alone are ineffective if the underlying cause is not treated, and thus fall outside the appropriate indications.

5. Usage and Dosage Restrictions: Patients must not increase the dose or extend the treatment duration without medical advice, as overdose may exacerbate adverse effects such as dizziness, nausea, and abdominal distension. Abrupt discontinuation of the drug is also prohibited. After liver function returns to normal, the medication should be tapered off gradually under physician guidance; sudden cessation may lead to rebound liver dysfunction.

Prior to use, patients should fully assess their health status and medication history and strictly follow medical instructions. Liver function should be regularly monitored during treatment to track changes in key indicators. Additionally, a light diet is recommended, alcohol consumption should be avoided, and overall hepatic burden minimized.