What are the contraindications of Roxithromycin Capsules?
Nov 06, 2025
Source: Cainiu Health
Dr. Huang Yuhong
Introduction
Pregnant women should decide whether to use the medication only after a physician has evaluated the potential benefits and risks, as the drug may cross the placenta and affect fetal development. Breastfeeding women must suspend breastfeeding during medication use to prevent the drug from entering the infant's body through breast milk. For infants and young children, dosages must be strictly adjusted according to age and weight to avoid risks associated with improper administration of capsule formulations or dosage errors.
Roxithromycin capsules are generally contraindicated in cases of drug allergy, special populations, drug interactions, specific diseases, and medication guidelines. The details are as follows:
1. Drug Allergy: Roxithromycin or macrolide antibiotics are strictly prohibited for individuals with known allergies. If allergic reactions such as rash, itching, laryngeal edema, or difficulty breathing occur after taking the medication, discontinue use immediately and seek medical attention. Patients with a history of allergies must inform their doctor before use to avoid triggering severe allergic reactions.
2. Special Populations: Pregnant women should only use roxithromycin after a physician has evaluated the risks and benefits, as the drug may cross the placenta and affect fetal development. Breastfeeding women should suspend breastfeeding during treatment to prevent the drug from passing into breast milk and affecting the infant. Pediatric dosing must be carefully adjusted according to age and weight to avoid risks associated with improper administration or incorrect dosage, especially with capsule formulations.
3. Drug Interactions: Concomitant use with ergot derivatives is prohibited, as it may lead to ergotism, causing symptoms such as vasoconstriction and limb ischemia. When used with theophylline, serum theophylline levels must be monitored to prevent elevated concentrations due to inhibited metabolism, which could result in side effects like nausea and arrhythmias. Patients should inform their doctor about all medications they are currently taking, including prescription drugs, over-the-counter medicines, and supplements.
4. Specific Diseases: Roxithromycin is contraindicated in patients with severe hepatic impairment, as the drug is primarily metabolized by the liver. Liver dysfunction can lead to drug accumulation and exacerbate liver damage. Patients with renal impairment should have their dosage and frequency adjusted under medical supervision to prevent adverse reactions caused by impaired drug excretion and to support kidney function recovery.
5. Medication Guidelines: Do not alter the prescribed dose or duration without medical advice. Underdosing may lead to bacterial resistance and reduced treatment efficacy, while overdosing may cause severe gastrointestinal reactions such as intense vomiting and diarrhea. Take the medication at the times specified by your doctor to maintain stable blood drug levels and ensure effectiveness; missing doses may reduce therapeutic outcomes.
Before taking roxithromycin capsules, carefully read the medication’s package insert and check whether your condition involves any contraindications. If you experience severe abdominal pain, jaundice, hearing abnormalities, or other discomforts during treatment, stop taking the drug immediately and consult a healthcare provider.
