What are the contraindications of Roxithromycin Tablets?
Nov 06, 2025
Source: Cainiu Health
Dr. Huang Yuhong
Introduction
Contraindications for Roxithromycin tablets generally include drug allergies, special populations, drug interactions, specific medical conditions, and usage instructions. Roxithromycin is contraindicated in individuals who are allergic to roxithromycin or other macrolide antibiotics. If allergic reactions such as rash, itching, or difficulty breathing occur after taking the medication, discontinue use immediately and seek medical attention. Patients with a history of allergies should inform their doctor prior to use to avoid the risk of severe allergic reactions.
Roxithromycin tablets are generally contraindicated in cases involving drug allergies, special populations, drug interactions, specific diseases, and usage/dosage considerations. A detailed analysis is as follows:
1. Drug Allergy: Roxithromycin or macrolide antibiotics are contraindicated in individuals with known allergies. If allergic reactions such as rash, itching, or difficulty breathing occur after taking the medication, discontinue use immediately and seek medical attention. Patients with a history of allergies should inform their doctor before use to avoid serious allergic risks.
2. Special Populations: Pregnant and breastfeeding women should only use roxithromycin after a physician has evaluated the risks and benefits. Self-medication is not recommended, as the drug may cross the placenta or be excreted in breast milk, potentially affecting the fetus or infant. Pediatric dosing must strictly follow age-appropriate guidelines to prevent adverse reactions due to incorrect dosage.
3. Drug Interactions: Concomitant use with ergot derivatives is prohibited, as it may lead to ergot toxicity. When used with theophylline, serum theophylline levels should be closely monitored to prevent impaired metabolism leading to elevated concentrations, which increases the risk of side effects such as nausea and arrhythmias. Patients must inform their doctor about all other medications currently being taken.
4. Specific Diseases: Roxithromycin is contraindicated in patients with severe hepatic impairment, as the drug is primarily metabolized in the liver. Liver dysfunction can lead to drug accumulation and increased hepatic burden. Patients with renal impairment should have their dosage adjusted under medical supervision to prevent adverse reactions due to reduced drug elimination.
5. Usage and Dosage: Do not alter the prescribed dose or extend the duration of treatment without medical advice. Underdosing may promote bacterial resistance, while overdosing may cause gastrointestinal side effects such as nausea, vomiting, and diarrhea. Follow the prescribed dosing schedule strictly to avoid missed doses that could compromise therapeutic effectiveness.
Before taking roxithromycin tablets, carefully read the product information leaflet and confirm whether any contraindications apply. If severe discomfort occurs during treatment—such as intense abdominal pain or jaundice—discontinue the medication immediately and consult a healthcare provider.
