Can progesterone prevent miscarriage?
Nov 11, 2025
Source: Cainiu Health
Dr. Zhang Lu
Introduction
In general, progesterone may help maintain a pregnancy in cases of threatened miscarriage caused by luteal phase deficiency or low progesterone levels, or following assisted reproductive technology. However, if the pregnancy complications are due to other factors such as embryonic chromosomal abnormalities or uterine malformations, progesterone is unlikely to be effective in preventing miscarriage. If you have any concerns, it is recommended to consult a healthcare provider in advance. A detailed analysis is as follows:
Generally, progesterone may help maintain a pregnancy in cases of threatened miscarriage caused by luteal phase deficiency or low progesterone levels, as well as in pregnancies following assisted reproductive technology. However, if the pregnancy complications are due to other factors such as embryonic chromosomal abnormalities or uterine malformations, progesterone is unlikely to be effective in preventing miscarriage. If there are concerns, it is recommended to consult a healthcare provider early. Detailed explanations are as follows:
If prenatal tests show progesterone levels below the normal range, and the pregnant woman experiences symptoms of threatened miscarriage such as light vaginal bleeding or mild abdominal pain, and ultrasound confirms normal embryonic development, the condition may be diagnosed as pregnancy instability due to luteal insufficiency. In such cases, progesterone supplementation under medical supervision can support embryonic development by increasing progesterone levels, potentially helping to maintain the pregnancy.
However, if miscarriage or abnormal pregnancy is caused by embryonic chromosomal abnormalities, or underlying issues such as uterine polyps, intrauterine adhesions, or infections, progesterone cannot address the root cause. In cases where embryonic demise or inevitable miscarriage has already occurred, using progesterone is not only ineffective but may also delay appropriate management. Therefore, progesterone is not recommended for maintaining pregnancy in these situations.
Pregnant women experiencing any discomfort should first seek medical evaluation to determine the underlying cause and avoid self-medicating with progesterone. During progesterone treatment, regular follow-up tests for progesterone levels and fetal development should be conducted as directed by a physician. If symptoms do not improve or worsen, prompt communication with the doctor is essential to adjust the treatment plan and ensure the safety of both mother and baby.
