Does sertraline cause weight loss or weight gain?

Sertraline is commonly available in tablet and capsule formulations. Generally, sertraline may lead to either weight loss or weight gain, depending on individual circumstances. The specific analysis is as follows:

Weight loss associated with sertraline is often related to reduced appetite during the initial phase of treatment. Some individuals may experience nausea and decreased appetite after starting the medication, leading to reduced food intake. Prolonged insufficient caloric intake can result in weight loss. This change typically occurs early in treatment; as the body gradually adjusts to the medication, appetite may recover, and the weight loss tends to stabilize.

Weight gain in some individuals may be a secondary effect following improved mood. Patients with depression often have poor appetite due to emotional disturbances. After treatment, as mood improves, appetite may return or even increase, resulting in higher food consumption and subsequent weight gain. Additionally, the medication might slightly affect metabolic function; long-term use combined with inadequate physical activity could contribute to gradual weight gain.

The impact of sertraline on body weight is bidirectional and should be evaluated based on the stage of treatment, individual metabolic differences, and lifestyle factors. If significant weight changes occur or are accompanied by discomfort, timely follow-up with a healthcare provider to adjust the treatment plan is recommended. Do not discontinue the medication without medical advice.