Can you lose weight after gaining weight from taking mirtazapine?

Nov 14, 2025 Source: Cainiu Health
Dr. Yang Ziqi
Introduction
In general, whether weight gain caused by taking mirtazapine can be lost depends on individual circumstances and should be assessed comprehensively. If any discomfort occurs, it is recommended to seek medical advice promptly. Maintain regular meal times daily, eat more foods rich in dietary fiber such as vegetables and whole grains, and avoid snacking before bedtime. Engage in 30 minutes of moderate-intensity exercise each day, such as jogging or swimming.

In general, whether weight gain caused by taking mirtazapine can be lost depends on individual circumstances and requires a comprehensive assessment. If any discomfort occurs, it is recommended to seek medical advice promptly. The specific analysis is as follows:

When weight gain results from increased appetite and slight metabolic changes due to the medication, and no long-term metabolic abnormalities are present, weight loss is usually achievable. Under a doctor's guidance, adjusting the medication regimen while controlling calorie intake, reducing high-sugar and high-fat foods, and regularly engaging in moderate exercise such as brisk walking or yoga, most individuals can gradually return to their previous weight within several months.

However, if weight gain is accompanied by complications such as hypothyroidism or insulin resistance, or results from prolonged overeating leading to significant fat accumulation, weight loss becomes more difficult. In these cases, medical evaluations are necessary to identify underlying conditions, and targeted treatment for the root causes is required. Relying solely on diet and exercise may lead to slow progress and a high risk of weight regain; therefore, long-term, comprehensive interventions are needed.

In daily life, maintain regular meal times, consume more fiber-rich foods such as vegetables and whole grains, and avoid late-night snacking. Engage in 30 minutes of moderate-intensity exercise daily, such as jogging or swimming. Monitor body weight regularly; if weight increases by more than 2 kg per month, consult a doctor promptly to evaluate the medication. Never discontinue or adjust the dosage without medical supervision.