What causes mild abdominal pain when using interferon, and what should be done?

Nov 14, 2025 Source: Cainiu Health

Dr. Zhang Lu

Introduction

In general, mild abdominal pain after using interferon may be caused by factors such as drug irritation of the intestines, emotional tension following medication, pelvic inflammatory disease, endometritis, or irritable bowel syndrome. It is recommended to seek medical attention promptly, identify the underlying cause, and then improve symptoms through general management, medication, or other treatments under a doctor's guidance. In daily life, it is important to keep the abdomen warm and avoid exposure to cold.

Generally, mild lower abdominal pain after using interferon may be caused by factors such as intestinal irritation from the medication, emotional tension following treatment, pelvic inflammatory disease, endometritis, or irritable bowel syndrome. It is recommended to seek medical attention promptly, identify the underlying cause, and then improve symptoms under a doctor's guidance through general management, medications, and other approaches. Specific analyses are as follows:

1. Intestinal irritation from medication: Interferon may stimulate the smooth muscles of the intestine, causing intestinal spasms and resulting in mild lower abdominal pain. Avoid consuming cold or raw foods immediately after taking the medication. Applying warm compresses to the abdomen may help relieve discomfort. Diet should primarily consist of warm, easily digestible foods.

2. Emotional tension after medication: Anxiety about treatment efficacy or side effects can lead to prolonged emotional stress, triggering autonomic nervous system dysfunction and causing mild lower abdominal pain. Practice deep breathing exercises for 15–20 minutes daily, relax through activities like walking or listening to soothing music, and avoid excessive worry.

3. Pelvic inflammatory disease: Inflammation caused by pathogen infection in pelvic tissues may worsen due to changes in immune status during treatment, accompanied by increased vaginal discharge and low back or sacral pain. Follow your doctor’s instructions to use medications such as ceftriaxone sodium injection, metronidazole tablets, or levofloxacin hydrochloride capsules to control infection. Avoid sexual intercourse during treatment.

4. Endometritis: Bacterial invasion causing inflammation of the endometrium may be exacerbated by interferon-induced local congestion, leading to mild lower abdominal pain. Follow your doctor’s advice to take medications such as clindamycin phosphate tablets, cefixime dispersible tablets, or azithromycin dry suspension. Maintain good personal hygiene and change underwear frequently.

5. Irritable bowel syndrome: Patients with pre-existing irritable bowel syndrome may experience symptom flare-ups triggered by interferon as an external stimulus, manifesting as mild lower abdominal pain and changes in bowel habits. Follow medical advice to use drugs such as pinaverium bromide tablets, bifidobacterium triple viable capsules, or trimebutine maleate tablets to alleviate symptoms.

In daily life, maintain warmth in the abdominal area and avoid chilling. Strictly follow the prescribed dosage and do not adjust the medication dose on your own. Maintain a regular lifestyle and adopt healthy living habits to help relieve discomfort.

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