Can depression relapse without any reason?

Generally, depression does not recur without cause; its recurrence is usually associated with multiple factors. A detailed analysis is as follows:

Depression relapse is often linked to incomplete treatment, stress-inducing events, and fluctuations in life circumstances. Some patients discontinue medication on their own after symptom relief, but neurotransmitter balance has not yet stabilized, making symptom recurrence more likely. Psychological stress from negative events such as unemployment or the loss of loved ones can disrupt emotional stability. Physiological disturbances caused by chronic sleep deprivation and irregular eating habits, or psychological emptiness resulting from social isolation, may also trigger relapse. These factors—acting individually or in combination—can lead to renewed dysfunction in brain neural circuits, causing the original symptoms to reappear.

After symptoms improve, it is essential to complete the full course of treatment as prescribed, and patients should never reduce or stop medication without medical guidance. Individuals should actively avoid known stressors and cultivate healthy emotion-regulation strategies such as meditation and physical exercise. Family members should pay close attention to the patient's emotional changes and provide timely support and companionship. Regular follow-up visits allow doctors to monitor disease progression. If signs such as low mood or reduced interest emerge, professional help should be sought immediately, as early intervention can effectively reduce the risk of recurrence.