Can Bifonazole Suppositories be used long-term?
Nov 14, 2025
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Metronidazole combined suppositories are not recommended for long-term use and should be used short-term according to the prescribed course. For indicated conditions such as bacterial, fungal, and mixed vaginitis, short-term standardized use can effectively control infection. However, prolonged indiscriminate use may lead to disturbances in vaginal microecology. Personal hygiene should be maintained during treatment, including frequent changing of cotton underwear, and sexual intercourse should be avoided.
Metronidazole and Clotrimazole Suppositories are not recommended for long-term use and should be used short-term according to the prescribed course. For indicated conditions such as bacterial, fungal, or mixed vaginitis, short-term standardized use can effectively control infection. However, prolonged and indiscriminate use may lead to disturbances in the vaginal microecosystem.
When used correctly and short-term, Metronidazole and Clotrimazole Suppositories exert therapeutic effects by inhibiting or killing pathogenic organisms. The medication should typically be used according to medical advice based on individual conditions—for example, a 7-day course. Once symptoms improve, the drug should be discontinued promptly to effectively address the infection while minimizing adverse effects on the body.
Prolonged use may disrupt the natural balance of vaginal flora, suppress the growth of lactobacilli, reduce the vagina's natural resistance, and thereby increase the risk of infection, potentially leading to recurrent episodes of vaginitis. Additionally, long-term use may promote antibiotic resistance in pathogens, reducing the effectiveness of future treatments.
During treatment, maintain good personal hygiene, frequently change into clean cotton underwear, and avoid sexual intercourse. Wash hands and the external genital area thoroughly before using the suppository, and strictly follow the instructions provided in the package insert or as directed by a healthcare provider.
