What are the topical medications for anal fistula?

Nov 14, 2025 Source: Cainiu Health
Dr. Li Jingxiang
Introduction
Topical medications for anal fistula include iodophor, potassium permanganate solution, compound calfactant cream, recombinant human epidermal growth factor gel, and erythromycin ointment. These are primarily used for cleansing and disinfection, relieving symptoms, and promoting wound healing, and should be used according to medical advice based on the condition. If skin redness, swelling, worsening itching, or abnormal wound conditions occur after medication use, prompt medical consultation is recommended.

Topical medications for anal fistula include iodophor, potassium permanganate solution, compound carrageenan cream, recombinant human epidermal growth factor gel, and erythromycin ointment. These are primarily used for cleaning and disinfection, symptom relief, and promoting wound healing. Medications should be used according to medical advice based on the specific condition. If skin redness, swelling, worsening itching, or abnormal wound changes occur after using the medication, prompt medical consultation is recommended.

1. Iodophor: Used for cleaning and disinfecting the perianal area and wound surface. It is mild and non-irritating, effectively kills local bacteria, and reduces the risk of infection. Apply before each dressing change or after defecation, covering both the wound and surrounding skin.

2. Potassium permanganate solution: Has antibacterial and astringent effects, suitable for sitz baths or wound irrigation. It helps inhibit bacterial growth and reduce inflammation and swelling. Must be diluted strictly according to the recommended ratio to avoid skin burns from excessive concentration.

3. Compound carrageenan cream: Relieves perianal pain and itching, protects the mucosal wound surface, and reduces friction irritation. After bowel movements, apply a thin layer to the cleaned and disinfected wound. Can be used following sitz baths.

4. Recombinant human epidermal growth factor gel: Promotes granulation tissue growth and accelerates wound healing. Suitable for slow postoperative wound recovery. Apply evenly after disinfection; avoid thick application to maintain wound breathability.

5. Erythromycin ointment: A topical antibiotic used to treat bacterial infections of the wound, helping alleviate symptoms such as redness, swelling, and pus formation. Should only be used when infection is confirmed, applied to infected areas as directed by a physician, and not overused long-term.

Prior to applying any topical medication, clean the perianal skin and keep the area dry. Strictly follow prescribed dosages and frequencies, and do not change medications without medical advice. Monitor wound changes during treatment, maintain a light diet, and ensure regular bowel movements to support recovery.