What does poorly differentiated colorectal cancer mean?

Low-grade differentiation in colorectal cancer refers to a low degree of cellular differentiation within the tumor tissue, meaning the cancer cells differ significantly from normal intestinal mucosal cells, exhibit immature morphology and function, have high malignancy, are prone to invasion and metastasis, and are associated with a relatively poor prognosis. If low-differentiated colorectal cancer is detected, it is recommended to seek timely medical evaluation, complete further diagnostic tests, and undergo standardized treatment.

Differentiation refers to how closely cancer cells resemble their corresponding normal cells. Higher differentiation indicates greater similarity to normal cells and lower malignancy. In contrast, low-differentiated cancer cells display abnormal shapes and functions, proliferate rapidly, more easily invade through the intestinal wall into surrounding tissues, and may metastasize to distant sites at an early stage.

Clinically, low-differentiated colorectal cancer is more challenging to treat and carries a higher risk of postoperative recurrence and metastasis compared to moderately or well-differentiated tumors. It often requires more aggressive treatment strategies, such as comprehensive therapies combining surgery with chemotherapy and/or radiotherapy, to reduce recurrence risk and prolong patient survival.

Patients should adhere to medical advice and complete prescribed treatments. Dietary choices should include light, easily digestible, and nutrient-rich foods. Maintaining regular sleep patterns, avoiding overexertion, engaging in moderate gentle exercise, managing emotional well-being, and undergoing regular follow-up examinations to monitor disease progression are also essential.