Will progesterone levels increase after taking dydrogesterone tablets?

Under normal circumstances, progesterone levels in blood tests usually do not show a significant increase after taking dydrogesterone tablets. The detailed explanation is as follows:

Dydrogesterone is a synthetic progestin whose chemical structure differs from endogenous progesterone naturally produced by the body. Most routine blood progesterone test kits are designed to detect endogenous progesterone and have low sensitivity toward dydrogesterone, making it difficult to accurately capture and include dydrogesterone in the test results. Additionally, dydrogesterone primarily exerts its effects through conversion into active metabolites in the body, rather than remaining in the bloodstream in its original form at high concentrations. This further contributes to low detectable levels of the parent drug in blood, resulting in no obvious elevation in measured progesterone levels.

It is important to take the medication exactly as prescribed by your doctor—do not adjust the dose or stop taking it without medical advice. If hormone monitoring is needed during treatment, inform your doctor beforehand that you are taking dydrogesterone, so they can make a comprehensive assessment based on clinical symptoms. Should you experience adverse effects such as nausea, dizziness, or vaginal bleeding, contact your doctor promptly and do not adjust your medication based solely on progesterone test results. Attend regular follow-up appointments so your doctor can evaluate treatment effectiveness according to your body's response and changes in your condition.