What should I do if the follicle hasn't ruptured even after two injections of ovulation-triggering shots?

After two injections of ovulation-triggering medication without ovulation occurring, management options include adjusting the dose of the triggering medication, switching to a different type of trigger, combining with other medications, delaying intercourse timing, or screening for underlying medical conditions. An individualized approach should be adopted based on specific circumstances. If ovulation continues to fail or is accompanied by discomfort, timely medical evaluation is recommended for further assessment.

1. Adjusting the dose of ovulation-triggering medication: If the previous dose was too low, the doctor may appropriately increase it based on follicle size and hormone levels to enhance the ovulation induction effect and promote follicular rupture and release. This must be strictly performed under medical supervision.

2. Switching the type of ovulation-triggering medication: Different ovulation triggers have slightly different mechanisms of action. If the current medication is ineffective, a switch to another type may be made under medical guidance—for example, changing from human chorionic gonadotropin (hCG) to a gonadotropin-releasing hormone (GnRH) agonist.

3. Combining with other medications: Additional drugs such as GnRH antagonists may be used in combination to regulate the internal hormonal environment, creating more favorable conditions for follicular rupture and improving the success rate of ovulation.

4. Delaying intercourse timing: Failure of the follicle to rupture may be due to slightly delayed development. Under medical monitoring, timing of intercourse or intrauterine insemination can be postponed to allow for natural ovulation, avoiding premature scheduling that could reduce the chance of conception.

5. Screening for underlying conditions: Conditions such as polycystic ovary syndrome (PCOS) or thyroid dysfunction may interfere with ovulation. Hormonal testing and thyroid function assessments are recommended to identify potential causes. Once diagnosed, treating the underlying condition before attempting ovulation induction can improve outcomes.

Maintain a regular daily routine and avoid staying up late, which can worsen endocrine disturbances. Eat a balanced diet rich in protein and vitamins. Engage in mild physical activities such as walking or yoga to help relax both body and mind, supporting normal follicular development and ovulation.